The qualitative research component for the INDEPTH Safety and Effectiveness Studies Platform is designed to provide insight into the contextual factors that affect people’s willingness and ability to seek care and provide appropriate treatment. To that end, the qualitative data collection activities for this project are conceptually integrated into the household and health facilities studies that are described in Modules 1 (Access), 3 (Provider Compliance), and 4 (Patient Adherence). To examine the social, cultural, and behavioral factors that facilitate or impede the uptake and adherence to new antimalarial combination therapies as they are introduced into real-life settings.