Cardiometabolic risk in a population of older adults with multiple co-morbidities in rural South Africa

24 Feb 2017
A consequence of the widespread uptake of anti-retroviral therapy (ART) is that the older South African population will experience an increase in life expectancy, increasing their risk for cardiometabolic diseases (CMD), and its risk factors. The long-term interactions between HIV infection, treatment, and CMD remain to be elucidated in the African population. The HAALSI (Health and Aging in Africa: longitudinal studies of INDEPTH communities) study cohort was established to investigate the impact of these interactions on CMD morbidity and mortality among middle-aged and older adults.
In the study, researchers recruited randomly selected adults aged 40 or older residing in the rural Agincourt sub-district in Mpumalanga Province in South Africa. In-person interviews were conducted to collect baseline household and socioeconomic data, self-reported health, anthropometric measures, blood pressure, high-sensitivity C-reactive protein (hsCRP), HbA1c, HIV-status, and point-of-care glucose and lipid levels. This cohort is experiencing an increased risk of CMD with age, as expected. Further, it appears that the HIV+ population has many of the chronic CMD risk factors to contend with as well. With the increase in co-morbidities associated with HIV-infection, their longer-term impact on screening, prevention, and treatment of CMD needs to be better understood. Read more