The Africa Centre Demographic Information System (ACDIS) started data collection in January 2000. The study population includes all household members, both resident and non-resident in the area. Demographic and health information is collected every three times a year from all registered households, with one senior household member reporting on all resident and non-resident individual members of the household. It includes reports of all births, deaths, marriages and moves into and out of the area. Household socio-economic data is collected once a year. All resident individuals over the age of 15 are interviewed annually and a dried blood spot taken for biomeasures, including HIV sero-status. The original demographic surveillance area is situated in the southern part of the Umkhanyakude district of KwaZulu-Natal (Mpukunyoni) and is approximately 440 square kilometres in size. It is home to about 14 000 households and about 90 000 people, of whom on average about one-third are non-resident household members. From 2017 this area will be extended by a further 400km2 for a total population under surveillance of 168,000.
*The Africa Centre for Population Health merged with the KwaZulu‐Natal Research Institute for Tuberculosis and HIV to form the Africa Health Research Institute (AHRI) on October 1, 2016.